Plant Transcription Factor Database
Previous version: v3.0
Brassica oleracea
ZF-HD Family
Species TF ID Description
XP_013585002.1ZF-HD family protein
XP_013588123.1ZF-HD family protein
XP_013588124.1ZF-HD family protein
XP_013588453.1ZF-HD family protein
XP_013590213.1ZF-HD family protein
XP_013590846.1ZF-HD family protein
XP_013590934.1ZF-HD family protein
XP_013596052.1ZF-HD family protein
XP_013596192.1ZF-HD family protein
XP_013596447.1ZF-HD family protein
XP_013599446.1ZF-HD family protein
XP_013599913.1ZF-HD family protein
XP_013599915.1ZF-HD family protein
XP_013599916.1ZF-HD family protein
XP_013599917.1ZF-HD family protein
XP_013602497.1ZF-HD family protein
XP_013602592.1ZF-HD family protein
XP_013602980.1ZF-HD family protein
XP_013603786.1ZF-HD family protein
XP_013603853.1ZF-HD family protein
XP_013606766.1ZF-HD family protein
XP_013607214.1ZF-HD family protein
XP_013609065.1ZF-HD family protein
XP_013609207.1ZF-HD family protein
XP_013610291.1ZF-HD family protein
XP_013613607.1ZF-HD family protein
XP_013613609.1ZF-HD family protein
XP_013613610.1ZF-HD family protein
XP_013614396.1ZF-HD family protein
XP_013616014.1ZF-HD family protein
XP_013616016.1ZF-HD family protein
XP_013616017.1ZF-HD family protein
XP_013616018.1ZF-HD family protein
XP_013616019.1ZF-HD family protein
XP_013616020.1ZF-HD family protein
XP_013618278.1ZF-HD family protein
XP_013618279.1ZF-HD family protein
XP_013618595.1ZF-HD family protein
XP_013623087.1ZF-HD family protein
XP_013623869.1ZF-HD family protein
XP_013624055.1ZF-HD family protein
XP_013624547.1ZF-HD family protein
XP_013624556.1ZF-HD family protein
XP_013631916.1ZF-HD family protein
XP_013631917.1ZF-HD family protein
XP_013639012.1ZF-HD family protein
XP_013639607.1ZF-HD family protein
ZF-HD Family Introduction

This group of sequences described by a 54-residue domain found in the N-terminal region of plant proteins, the vast majority of which contain a ZF-HD class homeobox domain toward the C terminus. The region between the two domains typically is rich in low complexity sequence. The companion ZF-HD homeobox domain is described in INTERPRO:IPR006455.

A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain proteins, which are most likely involved in the mesophyll-specific expression of the C4 PEPCase gene in C4 species of the genus Flaveria. Inspection of the homeodomains of the four proteins reveals that they share many common features with homeodomains described so far, but there are also significant differences. Interestingly, this class of homeodomain proteins occurs also in Arabidopsis thaliana and other C3 plants. One-hybrid experiments as well as in vitro DNA binding studies confirmed that these novel homeodomain proteins specifically interact with the proximal region of the C4 PEPCase (C4 phosphoenolpyruvate carboxylase) gene. The N-terminal domains of the homeodomain proteins contain highly conserved sequence motifs. Two-hybrid experiments show that these motifs are sufficient to confer homo- or heterodimer formation between the proteins. Mutagenesis of conserved cysteine residues within the dimerization domain indicates that these residues are essential for dimer formation. Therefore, we designate this novel class of homeobox proteins ZF-HD, for zinc finger homeodomain protein. Our data suggest that the ZF-HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene.

Windhovel A, Hein I, Dabrowa R, Stockhaus J.
Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
Plant Mol Biol. 2001 Jan;45(2):201-14.
PMID: 11289511